Evidence map›Paper›PMID 42789707›Full record

ArticleScience advances2026

Direct cellular contact by

Sena Chung, Doyun Kim, Byeonggeon Koh, Yeon Kyeong Ko, Kihwan Lee, Hayun Kim, Hyun Young Kim, Manda Yu, Ozge Erdogan, Larissa Staurengo-Ferrari and 4 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sena ChungDepartment of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University; Seoul, 08826, Republic of Korea.ORCID 0000-0003-2917-3039
Doyun KimDepartment of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University; Seoul, 03080, Republic of Korea.ORCID 0000-0002-9652-7602
Byeonggeon KohDepartment of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University; Seoul, 03080, Republic of Korea.ORCID 0000-0002-8801-660X
Yeon Kyeong KoDepartment of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute, Seoul National University; Seoul, 03080, Republic of Korea.ORCID 0000-0003-4439-2547
Kihwan LeeDepartment of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University; Seoul, 03080, Republic of Korea.ORCID 0000-0002-0468-4433
Hayun KimInterdisciplinary Program in Neuroscience, College of Natural Sciences, Seoul National University; Seoul, 08826, Republic of Korea.ORCID 0000-0002-6672-1375
Hyun Young KimDepartment of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University; Seoul, 03080, Republic of Korea.ORCID 0009-0004-2243-9396
Manda YuDepartment of Microbiology, ADA Forsyth Institute; Somerville, MA 02143, USA.ORCID 0000-0001-5932-9597
Ozge ErdoganDepartment of Restorative Dentistry and Biomaterial Sciences, Harvard School of Dental Medicine; Boston, MA 02115, USA.ORCID 0000-0002-6228-880X
Larissa Staurengo-FerrariDepartment of Immunology, Blavatnik Institute, Harvard Medical School; Boston, MA 02115, USA.
Isaac M ChiuDepartment of Immunology, Blavatnik Institute, Harvard Medical School; Boston, MA 02115, USA.ORCID 0000-0002-0723-4841
Mary E DaveyDepartment of Microbiology, ADA Forsyth Institute; Somerville, MA 02143, USA.ORCID 0000-0001-8129-0537
Youngnim ChoiDepartment of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute, Seoul National University; Seoul, 03080, Republic of Korea.ORCID 0000-0002-6496-5560
Seog Bae OhDepartment of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University; Seoul, 03080, Republic of Korea.ORCID 0000-0001-7975-6895

Funding

Microbial sphingolipids and suppression of host inflammation in periodontal diseaseR01DE031159 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN, GIBSON, FRANK C · 2021 to 2025
$2.9M
Regulatory Mechanisms Controlling P. gingivalis Surface StructuresR01DE033659 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Mary Ellen Davey · 2024 to 2026
$1.7M
NIDCR NIH HHS R01 DE031159NIDCR NIH HHS R01 DE033659
6 · The paper itself

Abstract

Pain often accompanies tissue injury and inflammation. However, in certain inflammatory contexts like periodontitis, nociceptive signaling is paradoxically suppressed. The mechanisms underlying this analgesic state remain poorly understood. Here, we investigated whether and how

Indexed as

AnalgesiaInflammationNociceptorsPainPorphyromonas gingivalisAnimalsCalcitonin Gene-Related PeptideHumansMiceCalcitonin Gene-Related Peptide

Identifiers

PMID42789707
PMCPMC13614394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.