SynthesisPloS one2026
Nonlinear dose-response of mind-body exercise in older adults with mild cognitive impairment: A systematic review and meta-analysis.
Synthesis in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to quantify domain-specific dose-response relationships between mind-body exercise and cognitive function in older adults with mild cognitive impairment (MCI), and to derive actionable dosing recommendation.
methodsEight major electronic databases were systematically searched up to September 15, 2025. Randomized controlled trials (RCTs) of mind-body exercise intervention in individuals aged ≥60 years with MCI that reported at least one cognitive domain outcome were included. Hedges'g effect sizes were calculated using random-effects models, and dose-response relationships were examined using restricted cubic spline regression.
resultsTwenty-seven RCTs (2034 participants) were included. Moderate-certainty evidence supported improvements in global cognition (Hedges' g: 0.67, 95% CI: [0.49, 0.78]) and processing speed (0.45 [0.3, 0.6]). Global cognition exhibited a U-shaped weekly dose-response, with 240 min/week as the relative nadir that still yielded a significant pooled effect (0.37; [0.19, 0.55]); longer intervention durations significantly amplified this overall response (β = 0.012, p < 0.05), and achieving significant benefit at this dose required ≥11 weeks intervention. Memory followed a similar pattern, but with very low certainty. Processing speed showed a U-shaped cumulative dose-response (nadir: 3400 minutes), and this effect was attenuated by weekly dose (β = -0.0011, p < 0.05), yet caution is warranted because the weekly doses in the included studies were heavily clustered.
conclusionsMind-body exercise produces domain-specific dose-response patterns in older adults with MCI. For global cognition, the observed U-shaped pattern suggests that if 240 min/week dose is adopted clinically, extending intervention to at least 11 weeks is advisable. However, prospective validation of these findings is needed before clinical application.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.