ArticleMolecular biology reports2026
Expression of long non‑coding RNAs DIAPH3‑AS1, HMMR‑AS1, and SPATA3‑AS1 in patients with colorectal cancer: association with chemotherapy response and clinicopathological features.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAntisense long non-coding RNAs (lncRNAs) may fine-tune expression of their overlapping sense genes in cancer. DIAPH3-AS1, HMMR-AS1, and SPATA3-AS1 remain uncharacterized in colorectal cancer (CRC), and SPATA3-AS1 has not been studied in any malignancy. METHODS AND
resultsNinety CRC patients were enrolled, with paired tumor biopsies collected before and after capecitabine-based chemotherapy; 71 healthy individuals served as controls. Expression of the three lncRNAs was measured by qRT-PCR and normalized to β-actin (2 - ΔCt method). Group and paired comparisons used the Mann-Whitney U and Wilcoxon signed-rank tests, and diagnostic value was assessed by ROC analysis. All three lncRNAs were significantly overexpressed in pre-treatment CRC tissue versus healthy mucosa (fold-changes 2.22-2.87; p < 0.001). After chemotherapy, HMMR-AS1 fell significantly (1.60-fold, p = 0.0012), becoming indistinguishable from controls (p = 0.133), whereas DIAPH3-AS1 and SPATA3-AS1 remained elevated. HMMR-AS1 was also higher in well/moderately differentiated than poorly differentiated tumors (p = 0.0067); none of the three transcripts was associated with TNM stage, lymph node metastasis, tumor site, or treatment response. ROC analysis showed modest baseline discrimination (AUC 0.652-0.699), and HMMR-AS1's diagnostic performance declined after treatment (AUC 0.569), consistent with its chemo-responsiveness.
conclusionsDIAPH3-AS1, HMMR-AS1, and SPATA3-AS1 are consistently upregulated in CRC tissue at diagnosis, but only HMMR-AS1 is sensitive to chemotherapy and differentiation grade, indicating transcript-specific roles for antisense lncRNAs in CRC biology.
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