ArticleIndian journal of pediatrics2026
Early versus Late Initiation of Enteral Feeding in Premature Infants (28-34 Weeks GA) with Growth Restriction and Absent or Reversed End-Diastolic Flow on Umbilical Artery Doppler: A Randomised Controlled Trial.
Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
The authors conducted an open-label RCT in growth-restricted preterm infants (28-34 wk) with Absent or Reversed end-diastolic flow on Antenatal Umbilical-Artery Doppler (AREDF) to compare early enteral feeding at 6 h (EIEF) with initiation at 48 h (LIEF). Eighty-seven infants were randomised (EIEF 44, LIEF 43). Feeds were advanced daily at 20, 40, 60, 90, 120, and 150 mL/kg/d, respectively, from the day of commencement of feeds. The primary outcome was time to full feeds; secondary outcomes included feed-intolerance (FI), NEC ≥ stage 2b, late-onset sepsis, mortality, and hospital stay. EIEF achieved full feeds earlier than LIEF (median 6 vs. 8 d). Rates of FI (20.9% vs. 25.6%), NEC (0 vs. 4.6%), mortality (6.8% vs. 16.3%), and hospital stay were not statistically different. Late-onset sepsis was lower with EIEF (6.8% vs. 27.9%). Early feeds from 6 h, with careful monitoring, enabled full feeds by day 6 without increasing adverse outcomes. The trial was registered prospectively at CTRI.org on 01/03/2019 (CTRI No. CTRI/2019/03/017899).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.