Evidence map›Paper›PMID 42789135›Full record

ArticleJournal of neuro-oncology2026

White matter pathlength maps from diffusion-weighted MRI tractography for radiotherapy target planning in glioblastoma.

Michael Wahl, Christopher H Chapman, Olivier Morin, Kesshi Jordan, Roland G Henry, Susan M Chang, Javier E Villanueva-Meyer, Pratik Mukherjee, Philip Theodosopoulos, Michael W McDermott and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael Wahl *Department of Radiation Oncology, University of California, Box 0226, 505 Parnassus Ave, 008, San Francisco, CA, 94117, USA.
Christopher H Chapman *Department of Radiation Oncology, University of California, Box 0226, 505 Parnassus Ave, 008, San Francisco, CA, 94117, USA.
Olivier MorinDepartment of Radiation Oncology, University of California, Box 0226, 505 Parnassus Ave, 008, San Francisco, CA, 94117, USA.
Kesshi JordanDepartment of Neurology, University of California, San Francisco, CA, USA.
Roland G HenryDepartment of Neurology, University of California, San Francisco, CA, USA.
Susan M ChangDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Pratik MukherjeeUCSF/UC Berkeley Graduate Program in Bioengineering, San Francisco & Berkeley, CA, USA.
Philip TheodosopoulosDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Michael W McDermottDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Mitchel S BergerDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Penny SneedDepartment of Radiation Oncology, University of California, Box 0226, 505 Parnassus Ave, 008, San Francisco, CA, 94117, USA.
Steve E Braunstein *Department of Radiation Oncology, University of California, Box 0226, 505 Parnassus Ave, 008, San Francisco, CA, 94117, USA. steve.braunstein@ucsf.edu.
Janine M Lupo *UCSF/UC Berkeley Graduate Program in Bioengineering, San Francisco & Berkeley, CA, USA. janine.lupo@ucsf.edu.

Funding

Congressionally Directed Medical Research Programs W81XWH2210695
6 · The paper itself

Abstract

purposeConventional radiotherapy target delineation for glioblastoma (GBM) includes an isotropic expansion from gross tumor visible on anatomic MRI to an empirically defined clinical target volume (CTV) for coverage of microscopic infiltrative disease. GBM spreads preferentially along white matter tracts, but this information has not previously been systematically incorporated into radiotherapy planning. We investigated using white matter tractography from diffusion-weighted MRI (dwMRI) to inform target delineation.

methodsThirteen patients with GBM underwent 55-directional dwMRI at the time of post-operative radiation planning MRI. Whole-brain tractography was performed, and streamlines passing within 5 mm of gross disease were used to generate maps representing white matter path length from gross disease. Clinical target volumes were generated using tractography (CTV

resultsCTV

conclusionTractography can be used to define CTV that may provide superior coverage of areas at risk of recurrence while simultaneously reducing target volume.

Indexed as

Brain NeoplasmsDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingGlioblastomaRadiotherapy Planning, Computer-AssistedWhite MatterAdultAgedFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedDiffusion-weighted MRIGlioblastomaRadiation therapy planningTractography

Identifiers

PMID42789135
PMCPMC13615038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.