ArticleEuropean journal of nuclear medicine and molecular imaging2026
The prognostic value of quantitative myocardial blood flow and flow reserve by dynamic CZT-SPECT for major adverse cardiovascular events.
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeCadmium-zinc-telluride single-photon emission computed tomography (CZT SPECT) enables myocardial blood flow (MBF) quantification using
methodsWe retrospectively included 1,007 consecutive patients who underwent dynamic [
resultsDuring a median follow-up of 49 months, MACEs occurred in 191 patients (19.0%). The optimal cutoffs were 1.96 mL/g/min for stress MBF and 1.98 for MFR. Abnormal flow was associated with worse MACE-free survival (χ² = 87.2, p < 0.001). In multivariable analysis, MFR and resting MBF remained independent predictors of a MACE after adjusting for clinical risk factors, stress left ventricular ejection fraction, and stress total perfusion deficit (sTPD). Quantitative flow assessment provided incremental risk stratification in patients with sTPD < 15%.
conclusionCZT SPECT-derived MBF and MFR provided independent prognostic information beyond conventional risk factors and static perfusion assessment, supporting their role in refining clinical risk stratification.
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