ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026
Adaptation and initial psychometric validation of the Latvian version of EORTC QLQ-C30 and QLQ-BR45 in women with breast cancer.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo culturally adapt and initially evaluate the psychometric properties of the Latvian versions of the EORTC QLQ-C30 and breast cancer-specific EORTC QLQ-BR45 in women with breast cancer.
methodsThe study was conducted within a pilot project implementing the ICHOM Breast Cancer Standard Set in a specialised university hospital in Latvia. Translation and cultural adaptation followed the EORTC procedure and included expert review and cognitive debriefing. Psychometric evaluation used baseline data from 142 women and six-month follow-up data from 47. Analyses included item-level indicators, internal consistency, multitrait scaling, inter-scale correlations, correlations with the Stress Symptom Scale, and paired change analyses. Conditional QLQ-BR45 items were treated as structurally missing when not applicable.
resultsExpert review and cognitive debriefing supported linguistic, conceptual, and cultural appropriateness. Reliability and item-scale correspondence were acceptable for several domains, with particularly strong multitrait scaling results for QLQ-BR45 Body Image, Sexual Functioning, and Breast Symptoms. Correlations between EORTC functioning and symptom domains and the Stress Symptom Scale were generally in the hypothesised directions. Six-month findings showed clinically plausible changes in functioning and treatment-related symptoms, but estimates were based on a smaller follow-up sample and reduced valid samples for some conditional scales.
conclusionThe Latvian EORTC QLQ-C30 and QLQ-BR45 showed acceptable preliminary psychometric performance. The findings provide initial support for their use to assess HRQoL and breast cancer-specific symptoms in Latvia, while larger multicentre and longitudinal studies are needed to evaluate additional measurement properties and responsiveness.
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