ArticleCell biochemistry and biophysics2026
Antitumor Activity of Mitochondrial Uncouplers Based on Platinum (II) N-Heterocyclic Carbene Complexes.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
In the present study, the effects of mitochondrial uncouplers on lung carcinoma cells were investigated. The compounds were found to inhibit cell proliferation by inducing cell cycle arrest at the G1/S transition. Treatment with the tested complexes led to acidification of the extracellular medium, associated with enhanced lactate production due to compensatory increase in glycolytic flux. The effect on HIF signalling has been demonstrated, which is especially intriguing when considering how to overcome neoplastic cells' resistance to chemical agents. Signaling pathway analysis revealed that mitochondrial uncoupling increased ERK1/2 phosphorylation levels, which may represent a compensatory cellular response to energy stress. Exposure to the complexes also resulted in elevated reactive oxygen species (ROS) generation and pronounced morphological alterations. These findings provide further insight into the mechanisms of action of mitochondrial uncouplers and their impact on proliferation, metabolism, and signaling pathways in tumor cells.
Indexed as
Identifiers
42789015What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.