ArticleChemistry & biodiversity2026
Development of Dithioacetal-Modified Dihydropyrimidone Derivatives with Potential Anti-Inflammatory Activity for Inflammatory Bowel Disease.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder, and the development of novel anti-inflammatory small molecules is crucial for advancing therapeutic options. In this study, we designed and synthesized a series of novel dihydropyrimidinone derivatives containing dithioacetal groups. Through in vitro safety assessments and anti-inflammatory screening, we identified several compounds with promising biological activities. Notably, compound D3 exhibited exceptional anti-inflammatory effects, demonstrating an IC
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