ArticleRevista da Associacao Medica Brasileira (1992)2026
Effects of bromelain on endocannabinoid system and oxidative stress in a rat model of endometriosis.
Article in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe objective of this study is to evaluate the effects of bromelain on serum endocannabinoid levels and oxidative stress markers in a rat model of surgically induced endometriosis.
methodsA total of 24 female Wistar albino rats were randomly assigned to three groups (n=8 each): Sham, endometriosis, and endometriosis treated with bromelain (endometriosis+B). Endometriosis was induced by autotransplantation of uterine tissue. Bromelain (20 mg/kg/day) was administered orally for 15 consecutive days. Serum levels of 2-arachidonoylglycerol, anandamide, superoxide dismutase, glutathione, and malondialdehyde were measured using ELISA. Statistical analysis was performed using one-way analysis of variance followed by Tukey's post hoc test.
resultsInduction of endometriosis significantly reduced serum 2-arachidonoylglycerol, anandamide, superoxide dismutase, and glutathione levels while increasing malondialdehyde concentrations compared with the Sham group (p<0.05). Bromelain treatment significantly improved most endocannabinoid and oxidative stress parameters compared with the untreated endometriosis group (p<0.05).
conclusionBromelain ameliorated endocannabinoid deficiency and oxidative stress in experimental endometriosis. These findings suggest that bromelain may represent a promising non-hormonal therapeutic candidate targeting interconnected inflammatory and redox pathways in endometriosis.
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