Trial reportJournal of cachexia, sarcopenia and muscle2026
Skeletal Muscle Transcriptomic Responses to Concurrent Training With Polyphenols in Ageing Adults: A Randomized Trial.
Trial report in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundTranscriptomic adaptations of ageing skeletal muscle to concurrent resistance training (RT) and high-intensity interval training (HIIT) remain insufficiently characterized. We investigated the effects of a 12-week concurrent RT + HIIT intervention on the vastus lateralis transcriptome in middle-aged and older adults and whether polyphenol supplementation modulated these responses.
methodsThirty-eight adults (55-70 years; 17 polyphenol [PP], 21 placebo [PLA]) with paired skeletal muscle RNA-sequencing data participated in a randomized, double-blind trial. Participants completed a 30-day supplementation phase followed by a 12-week supervised RT + HIIT programme with continued supplementation. Muscle biopsies were obtained before (PRE) and after (POST) training. Differential expression analyses were adjusted for age, sex and muscle fibre type composition. Differential expression was assessed using FDR ≤ 0.05, with |log
resultsBaseline transcriptomic differences between PP and PLA groups were minimal, with three FDR-significant transcripts, of which only HMOX1 additionally exceeded |log
conclusionsIn middle-aged and older adults, 12 weeks of concurrent RT + HIIT induced a predominantly low-magnitude skeletal muscle transcriptional response. Selected transcript-level changes were consistent with processes related to extracellular matrix remodelling and contractile regulation; however, the absence of robust pathway-level enrichment limits conclusions regarding coordinated biological pathway adaptations. Polyphenol supplementation did not meaningfully influence the transcriptional response to exercise training.
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