ArticleWorld journal of nuclear medicine2026
Diuretic-Enhanced Dual-Phase F-18 FDG PET/CT: A New Window Into Muscle-Invasive Bladder Cancer.
Article in World journal of nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to assess the diagnostic performance of diuretic-enhanced dual-phase F-18 FDG PET/CT in detecting muscle invasion in bladder cancer (BC) and to evaluate the predictive role of metabolic and volumetric PET parameters. Methods: A total of 105 patients (85 males, 20 females; mean age: 67.8 years) with suspected BC underwent F-18 FDG PET/CT for initial staging. Routine and delayed pelvic imaging was performed after intravenous furosemide. Metabolic and volumetric parameters, including SUV Results: Distant metastases were detected in 30 patients (28.5%), which directly influenced treatment decisions. In the TUR-B cohort ( Conclusion: Diuretic-enhanced dual-phase F-18 FDG PET/CT provides clinically valuable information for the assessment of detrusor muscle invasion and the differentiation of bladder lesions. Quantitative volumetric and metabolic parameters may serve as surrogate biomarkers, supporting preoperative staging and contributing to more precise, personalized treatment strategies for patients with BC.
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