Evidence map›Paper›PMID 42788117›Full record

ArticlePediatrics open science2025

Comorbidities in Adolescents With Congenital Heart Disease: A Population-based Study.

Matthew R Reeder, Lorenzo D Botto, George K Lui, Marcia L Feldkamp, M Jill Glidewell, Wendy M Book, Tessa Crume, Jesse M DeLaRosa, Alfred d'Ottavio, Karrie F Downing and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Matthew R ReederDivision of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah.
Lorenzo D BottoDivision of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah.
George K LuiStanford University School of Medicine, Palo Alto, California.
Marcia L FeldkampDivision of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah.
M Jill GlidewellNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.
Wendy M BookDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia.
Tessa CrumeColorado School of Public Health, University of Colorado Anschutz Medical Center, Aurora, Colorado.
Jesse M DeLaRosaDuke Clinical Research Institute, Durham, North Carolina.
Alfred d'OttavioDuke Clinical Research Institute, Durham, North Carolina.
Karrie F DowningNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.
Daphne T HsuChildren's Hospital at Montefiore and Albert Einstein College of Medicine, Bronx, New York.
Amber D KhannaDivision of Cardiology, Departments of Internal Medicine and Pediatrics, Colorado School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Sergey KrikovDivision of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah.
Nelangi PintoDivision of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah.
Cheryl L Raskind-HoodDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia.
Fred H RodriguezDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia.
Aida S SoimNew York State Department of Health, Albany, New York.
Kevin J WhiteheadDivision of Cardiovascular Medicine, Department of Internal Medicine, Salt Lake City, Utah.
Karen ChiswellDuke Clinical Research Institute, Durham, North Carolina.
Jennifer S LiDuke Clinical Research Institute, Durham, North Carolina.

Funding

Sharing statewide health data for genetic research (1 R01 RR021746-01A1)R01RR021746 · NCRR · UNIVERSITY OF UTAH · PI MINEAU, GERALDINE P · 2007 to 2009
$770k
Intramural CDC HHS CC999999NCRR NIH HHS R01 RR021746
6 · The paper itself

Abstract

objectivesWe evaluated the frequency and patterns of comorbidity and multimorbidity in adolescents with congenital heart disease (CHD) using data from a multisite population-based surveillance project.

methodsAdolescents aged 11 to 18 years with at least 1 CHD-related diagnosis code and residing in one of 5 geographic areas in the US were identified using linked clinical and administrative data sources for the years 2011 to 2013. Sites linked data on all inpatient, emergency department, and outpatient visits. Multivariate Poisson regression with robust error estimates was used to assess the association of comorbidity with age, sex, insurance type, race, ethnicity, and CHD severity.

resultsThe study included 9626 adolescents. Of these, 26% had severe CHDs. Overall, 68% had at least one comorbidity during the study period, and 46% had multiple comorbidities. Noncardiac comorbidities (55%) were more frequent than cardiac comorbidities (40%). Major noncardiac comorbidities included mental health conditions, neurodevelopmental disorders, pulmonary obstructive disease, nutrition-related (overweight, obesity) conditions, and endocrine conditions. Cardiac comorbidities included arrhythmias and residual cardiac disease. Variations by age and sex were minimal, but a higher burden of comorbidity and multimorbidity was associated with CHD severity, multiracial background, and public insurance.

conclusionsComorbidities, both cardiac and noncardiac, are prevalent in adolescents with CHD, underscoring the need for targeted care strategies in this age group and effective transition programs from pediatric to adult CHD care.

Identifiers

PMID42788117
PMCPMC13606679

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