Evidence map›Paper›PMID 42788050›Full record

ArticleSynthesis2026

Synthesis and Biological Evaluation of O6C-Salvinorin Alkyne Probes.

Etienne Cotter, Giovanni Leoni, Nathan Dao, Sarah J Hill, Alexandra Faragher, Vuong Q Dang, Laura M Bohn, Ryan A Shenvi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Etienne CotterDepartment of Chemistry, Scripps Research, La Jolla, California 92037, United States.
Giovanni LeoniDepartment of Chemistry, Scripps Research, La Jolla, California 92037, United States.
Nathan DaoDepartment of Chemistry, Scripps Research, La Jolla, California 92037, United States.
Sarah J HillDepartment of Chemistry, Scripps Research, La Jolla, California 92037, United States.
Alexandra FaragherDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, United States.
Vuong Q DangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, United States.
Laura M BohnDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, United States.
Ryan A ShenviDepartment of Chemistry, Scripps Research, La Jolla, California 92037, United States.

Funding

Mapping brain-wide opioid actions by profiling neuronal activities and in vivo cellular target engagementR01DA059393 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI Laura M. Bohn, Ryan Ashok Shenvi · 2023 to 2026
$3.3M
NIDA NIH HHS R01 DA059393
6 · The paper itself

Abstract

The salvinorins represent a unique class of polyoxygenated, non-nitrogenous diterpenes that potently and selectively modulate the

Indexed as

1,4-conjugate additionalkyne probeCATCH assayopioid receptororganozincReformatsky reactionSalvinorin A

Identifiers

PMID42788050
PMCPMC13604019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.