Oriented hydrogel biomimicking muscle fibers to treat pelvic organ prolapse via integrated immunomodulation and electrical stimulation.

Xinting Yang, Hongru Li, Yubin Feng, Chenke Wei, Yukai Guo, Bai Yang, Tianmin Xu, Quan Lin

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xinting YangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Avenue, Changchun, 130012, China.

Hongru LiDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University, 4026 Yatai Street, Changchun, 130000, China.

Yubin FengState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Avenue, Changchun, 130012, China.

Chenke WeiState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Avenue, Changchun, 130012, China.

Yukai GuoState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Avenue, Changchun, 130012, China.

Bai YangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Avenue, Changchun, 130012, China.

Tianmin XuDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University, 4026 Yatai Street, Changchun, 130000, China.

Quan LinState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Avenue, Changchun, 130012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic organ prolapse is a displacement disorder caused by the weakening of pelvic support tissues, leading to severe urinary incontinence, compromised organ support, and a high recurrence risk. Although clinically used polypropylene meshes provide mechanical reinforcement, their inherent stiffness often causes persistent mechanical overstimulation and chronic inflammation, ultimately resulting in implantation failure. Here, inspired by the parallel-aligned architecture of muscle fibers, we fabricate an oriented and hydrophilic hydrogel via directional freezing, composed of poly(vinyl alcohol), glycyrrhizic acid, Zn

Indexed as

Conductive hydrogelElectrical stimulationOriented hydrogelPelvic organ prolapse

Identifiers

PMID42787957

DOI10.1016/j.mtbio.2026.103658

PMCPMC13602707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.