Evidence map›Paper›PMID 42787924›Full record

ArticleResuscitation plus2026

Feasibility of multi-domain data acquisition in patients at risk for hypoxic-ischemic brain injury following cardiac arrest: a prospective cohort study.

Dallas Genereaux, Bobo Tong, Penelope M A Brasher, Ryan L Hoiland, Mypinder S Sekhon, Tison Schoenthal, Noah D Silverberg, Nishtha Parag, William Panenka, Rebecca Grey and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Dallas GenereauxDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.
Bobo TongDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.
Penelope M A BrasherCentre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Canada.
Ryan L HoilandDepartment of Cellular & Physiological Sciences, University of British Columbia Okanagan, Canada.
Mypinder S SekhonDepartment of Medicine, Division of Critical Care Medicine, University of British Columbia, Canada.
Tison SchoenthalDepartment of Medicine, Division of Critical Care Medicine, University of British Columbia, Canada.
Noah D SilverbergDepartment of Psychology, University of British Columbia, Canada.
Nishtha ParagDepartment of Psychology, University of British Columbia, Canada.
William PanenkaDepartment of Psychiatry, University of British Columbia, Canada.
Rebecca GreyDepartment of Medicine, Division of Critical Care Medicine, University of British Columbia, Canada.
Philip N AinslieSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Canada.
Thalia S FieldDepartment of Medicine, Division of Neurology, University of British Columbia, Canada.
Anish R MitraDepartment of Medicine, Division of Critical Care Medicine, University of British Columbia, Canada.
Sophie StukasDepartment of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Canada.
Cheryl L WellingtonDepartment of Pathology and Laboratory Medicine, University of British Columbia, Canada.
Katie N DaintyDalla Lana School of Public Health, Institute of Health Policy, Management, and Evaluation, Canada.
Carmen ChoiUrban patient and family partner, Canada.
Christopher B FordyceDepartment of Medicine, Division of Cardiology, and the Centre for Cardiovascular Innovation, Vancouver General Hospital, University of British Columbia, Canada.
Farzad Moien-AfshariDepartment of Medicine, Division of Neurology, University of British Columbia, Canada.
Erin Camille A CaritativoEpilepsy Clinic, Vancouver General Hospital, Vancouver Coastal Health, Canada.
Manraj K S HeranDepartment of Radiology, University of British Columbia, Canada.
William R HendersonDepartment of Medicine, Division of Critical Care Medicine, University of British Columbia, Canada.
Donald E G GriesdaleDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypoxic-ischemic brain injury is a determinant of neurologic injury and death among survivors of cardiac arrest. While neurophysiologic and biomarker changes may improve prognostication, the feasibility of acquiring multimodal physiologic, biologic, imaging, and patient-centered outcome data across the continuum of care is not established. Objective: To evaluate the feasibility of (1) patient recruitment; (2) acquiring multi-domain variables; and (3) six-month post-discharge outcomes in a cohort of patients with hypoxic-ischemic brain injury after cardiac arrest. Methods: We conducted a feasibility study of adults admitted to a critical care unit following cardiac arrest. In-hospital data collection included serum biomarkers, transcranial Doppler, neuroimaging, and electroencephalography. Post-discharge outcomes were assessed in-person or remotely at 6-months, and included outcome assessments, biomarkers, and MRI brain. Feasibility was defined a priori. Results: Thirty participants were enrolled (June 2022-May 2023). Biomarker samples were obtained in 29/30 (97%) participants on Day 1, 28/29 (97%) evaluable participants on Day 2, 21/25 (84%) on Day 3, and 12/17 (71%) on Day 7. Transcranial Doppler was completed in 23/30 (77%) participants, limited by inadequate acoustic windows and technical failures. All participants underwent either CT or MRI, and 23/30 (77%) had electroencephalography. Modified Rankin Scale was obtained in 27/30 (90%) participants. At least one six-month follow-up assessment was completed in 9/12 (75%) hospital survivors, while the complete in-person multidomain battery was completed in 4/12 (33%). Follow-up MRI was completed in 1/4 in-person follow-up attendees. Conclusions: Early serum biomarker specimen acquisition was feasible, and remote or proxy-assisted approaches increased six-month outcome ascertainment. However, serial transcranial Doppler, later biomarker sampling, systematic MRI acquisition, and full multidomain follow-up were limited by operational and patient-related barriers, particularly the challenges of in-person assessment.

Indexed as

Cardiac arrestFeasibility studyHypoxic-ischemic brain injuryPrognostication

Identifiers

PMID42787924
PMCPMC13602316

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.