Loss of novel mechanosensitive ion channel TMEM63A impairs osteogenic differentiation and proliferation via disruption of cellular mechanotransduction.

Meghana Davuluri, Rekha Sathian, Anna R Cho, Ramana V Davuluri, Yi-Xian Qin

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Article in Mechanobiology in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Meghana DavuluriDepartment of Biomedical Engineering, Stony Brook University, New York, United States.

Rekha SathianDepartment of Biomedical Informatics, Stony Brook University, New York, United States.

Anna R ChoDepartment of Biomedical Engineering, Stony Brook University, New York, United States.

Ramana V DavuluriDepartment of Biomedical Informatics, Stony Brook University, New York, United States.

Yi-Xian QinDepartment of Biomedical Engineering, Stony Brook University, New York, United States.

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6 · The paper itself

Abstract

Skeletal homeostasis depends critically on the local mechanobiological microenvironment. While well-known mechanosensitive ion channels like Piezo1 and Piezo2 translate physical forces into immediate membrane ion fluxes, the proximal sensors regulating medium- and long-term osteogenic pathways remain poorly understood. Low-intensity pulsed ultrasound (LIPUS) is widely used clinically to accelerate fresh fracture repair, yet its underlying upstream mechanotransduction machinery is not fully characterized. Here, we identify TMEM63A - a stretch-activated cation channel - as a crucial mechanosensor required for mechanical stimuli-driven osteogenic differentiation and anabolic signaling for sustained response to the force. Thus, the

Indexed as

Bone cell mechanobiologyCalcium signalingLIPUSMechanosensitive ion channelMechanotransductionOsteoblast differentiationOsteoblastogenesisRNA sequencingTMEM63AWnt/β-catenin

Identifiers

PMID42787916

DOI10.1016/j.mbm.2026.100212

PMCPMC13602320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.