ArticleMedical research archives2026
Exploring the Relationship Between Dolutegravir and Diabetes Using Routine Data of Patients on Anti-Retroviral Treatment in a High HIV Prevalence Setting.
Article in Medical research archives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Background: Dolutegravir has been associated with excessive weight gain and type 2 diabetes mellitus (T2DM) The study aimed to describe the incidence and prevalence of type 2 diabetes mellitus in a cohort of patients exposed and non-exposed to dolutegravir containing antiretroviral therapy in Eswatini. Methods: We conducted a retrospective observational study using routinely collected data from electronic medical records for adults aged ≥25years active on antiretroviral therapy in two of the country's regions between 01 October 2018 and 31 August 2025. Included patients were adults (≥25 years) active on antiretroviral therapy with no prior diagnosis of diabetes mellitus. The primary outcome was a documented diagnosis of type 2 diabetes mellitus among dolutegravir initiators- patients who started antiretroviral therapy on a dolutegravir-based regimen; dolutegravir transitioners- patients previously on a non-dolutegravir regimen who transitioned to a dolutegravir-based regimen; and non- dolutegravir users- patients that were never exposed to dolutegravir. Multiple imputation was used to handle missing data in body mass index and antiretroviral therapy duration. Descriptive statistics were used to describe patient characteristics, and Poisson log link regression was used to compute incidence risk ratios. Results: A total of 102330 patients were analyzed (21938 in dolutegravir initiators group, 73967 in dolutegravir transitioners group and 6425 in non-dolutegravir users group). The participant mean age was 43.7±11.7years, the mean duration on antiretroviral therapy was 9.4±3.9years and mean body mass index (BMI) was 27.5±6.2 kg/m Conclusion: There was a protective relationship for developing type 2 diabetes mellitus for patients on dolutegravir-based regimens in comparison to non-dolutegravir regimens. All patients commencing antiretroviral therapy should have baseline and ongoing blood glucose monitoring as a critical component in the management of HIV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.