ArticleSovremennye tekhnologii v meditsine2026
Optimization of the Nitinol Framework of an Aortic Valve Bioprosthesis Using Numerical Simulation.
Article in Sovremennye tekhnologii v meditsine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of numerical analysis methods when developing novel heart valve bioprostheses is an integral stage of their design; it enables to optimize the bioprosthetic construction and accelerate their development process. Materials and Methods: The study investigated an aortic valve bioprosthesis with a self-expanding nitinol frame and the leaflet apparatus of three biological leaflets fixed to the frame through the holes in the commissural posts. The bioprosthesis was tested on a test bench to evaluate the hydrodynamic characteristics of heart valve prostheses. A computer model of the valve frame was created for a finite element analysis in the COMSOL Multiphysics software environment, and validated based on the observed deformations of the bioprosthesis in a full-scale experiment. The obtained model was used for parametric optimization of the commissural post geometry to reduce their deformities. Results: Bench hydrodynamic tests revealed significant deformities of the bioprosthetic commissural posts (bending up to 5 mm) in leaflet closure under diastolic pressure. The numerical simulation using the finite element method enabled to precise the load on the posts (1.3 N instead of 1.52 N according to preliminary calculations). Based on the results obtained, an optimized frame design was developed with increased width and thickness of the beams in the area of commissural posts (from 0.3 to 0.5 mm and from 0.4 to 0.5 mm, respectively). Finite element analysis showed the suggested modification to significantly increase the structural stiffness, reducing the deformation value to 0.7 mm under the load of 1.3 N. Conclusion: The suggested approach to the application of numerical simulation demonstrated its effectiveness for optimizing the design of the nitinol frame of a transcatheter aortic valve bioprosthesis. The suggested modification of the commissural post geometry significantly reduced their deformity under the hydrodynamic load on the valve, which contributed to the preservation of the leaflet coaptation, reduced the risk of paravalvular regurgitation and prosthesis dislocation. The findings demonstrate the promise of using numerical simulation methods at a bioprosthetic design stage enabling to reduce the number of necessary physical prototypes and accelerate the development process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.