Evidence map›Paper›PMID 42787710›Full record

ArticleRSC advances2026

Quinazolinone-diarylpyrazole hybrids as dual EGFR/COX-2 inhibitors: antiproliferative, mechanistic, and

Abdullah Alkhammash, Basima A A Saleem, Khulood H Oudah, Mohamed Ahmed, Kasim Sakran Abass, Sara Mahmoud Farhan, Magdi E A Zaki, Sobhi M Gomha

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdullah AlkhammashDepartment of Pharmacology, College of Pharmacy, Al-Dawadmi Campus, Shaqra University Shaqra 11961 Saudi Arabia.ORCID https://orcid.org/0009-0002-2000-2620
Basima A A SaleemDepartment of Chemistry, College of Science, University of Mosul Mosul 41001 Iraq.ORCID https://orcid.org/0000-0002-5947-701X
Khulood H OudahDepartment of Pharmacy, Mazaya University College Nasiriyah Iraq.ORCID https://orcid.org/0000-0002-5014-7129
Mohamed AhmedCollege of Medicine, Dhofar University Salalah 122 Oman.ORCID https://orcid.org/0000-0003-1943-8419
Kasim Sakran AbassDepartment of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Kirkuk Kirkuk 36001 Iraq kasim_abass@uokirkuk.edu.iq.ORCID https://orcid.org/0000-0002-5796-7170
Sara Mahmoud FarhanDepartment of Microbiology and Immunology, Faculty of Pharmacy, Deraya University New Minia 61768 Egypt.ORCID https://orcid.org/0000-0002-7857-2020
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia.ORCID https://orcid.org/0000-0002-5643-9202
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah Madinah 42351 Saudi Arabia smgomha@iu.edu.sa.ORCID https://orcid.org/0000-0002-7739-2837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal epidermal growth factor receptor (EGFR) signaling and cyclooxygenase-2 (COX-2) mediated inflammatory pathways contribute to tumor progression and survival, supporting their simultaneous pharmacological targeting. Herein, a series of quinazolinone-diarylpyrazole hybrids 7a-l was designed, synthesized, and evaluated as dual EGFR/COX-2 inhibitors. Compound 7f exhibited the most balanced inhibitory profile against the two targets, exhibiting EGFR and COX-2 IC

Identifiers

PMID42787710
PMCPMC13603062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.