ArticleIranian journal of basic medical sciences2026
Evaluation of excretory-secretory products of
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Zoonotic cutaneous leishmaniasis is an infectious disease caused by the protozoan parasite Materials and Methods: The ES was collected, filter-sterilized, and loaded onto chitosan nanoparticles (CN). The ES-loaded CN was applied at different concentrations under both Results: ES-loaded chitosan nanoparticles were more effective in healing leishmanial lesions than the crude ES and chitosan nanoparticles applied separately. The ES-loaded CN exhibited stronger inhibitory effects against both intracellular and extracellular forms of the parasite than its components did when used alone. Conclusion: The results indicated that ES- loaded chitosan nanoparticles exerted antileishmanial and immunomodulatory effects on lesions. The formulation may therefore represent a promising alternative remedy for treating leishmanial lesions. Due to their biocompatibility, antimicrobial activity, and controlled-release capability, ES-loaded CN showed effective performance in wound healing and treatment.
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