Timing-dependent inhibitory effects of peripheral somatosensory inputs on the primary motor cortex: A transcranial magnetic stimulation-electroencephalography study.

Tomoya Kokue, Ryoki Sasaki, Kenichi Sugawara

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Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

3 authors.

Tomoya KokueGraduate Course of Health and Social Services, Kanagawa University of Human Services, Heisei-cho 1-10-1, Yokosuka City, Kanagawa, 238-8522, Japan.

Ryoki SasakiGraduate Course of Health and Social Services, Kanagawa University of Human Services, Heisei-cho 1-10-1, Yokosuka City, Kanagawa, 238-8522, Japan.

Kenichi SugawaraGraduate Course of Health and Social Services, Kanagawa University of Human Services, Heisei-cho 1-10-1, Yokosuka City, Kanagawa, 238-8522, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short-latency afferent inhibition (SAI) is a transient suppression of corticomotor excitability elicited by peripheral electrical stimulation (ES). When the interstimulus interval (ISI) between ES and transcranial magnetic stimulation (TMS) was set to 2 or 5 ms after the estimated arrival of somatosensory input in the primary somatosensory cortex, motor-evoked potentials (MEPs) were suppressed compared with single-pulse TMS. Previous studies have shown that the inhibitory activity depends on the timing between ES and TMS. However, whether subtle differences in afferent timing modulate TMS-evoked cortical responses remains unclear. To address this, we examined whether subtle ISI differences modulate cortical responses by SAI using TMS-electroencephalography (TMS-EEG). Thirty healthy adults (21.9 ± 4.4 years) participated in the current study. The ISI was determined relative to the N20 latency of somatosensory-evoked potential. MEPs were measured under three conditions: single-pulse TMS (TMS-alone), SAI with an ISI of N20 + 2 ms (SAI

Indexed as

Electrical stimulationPrimary motor cortexShort-latency afferent inhibitionTranscranial magnetic stimulation-electroencephalographyTranscranial magnetic stimulation-evoked potential

Identifiers

PMID42787703

DOI10.1016/j.ynirp.2026.100407

PMCPMC13602058

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.