Evidence map›Paper›PMID 42787691›Full record

ReviewNPJ autoimmunity2026

Neurotransmitters as regulators of autoimmunity: mechanisms and translational targeting.

Taruna Lamba, George C Tsokos

Abstract readReview
In one paragraph

Review in NPJ autoimmunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Taruna LambaDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA.
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA.

Funding

Project 2 - BWHP01AI179405 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Reza Abdi · 2024 to 2026
$8.9M
NIAID NIH HHS P01 AI179405
6 · The paper itself

Abstract

Autoimmune diseases arise from sustained breakdown of immune tolerance, chronic activation of innate and adaptive immune responses, and progressive tissue damage. Although cytokines, antigen receptor signaling, and genetic susceptibility have traditionally been considered the principal drivers, increasing evidence demonstrates that neurotransmitters have an underappreciated role in the pathogenesis of autoimmune diseases. The neuroimmune interactions link neural activity, psychological stress, and tissue innervation to autoimmune disease development, progression, and relapse. In this review, we integrate current mechanistic studies demonstrating how neurotransmitters regulate innate and adaptive immune responses and discuss their role in autoimmune diseases.

Indexed as

ImmunologyNeurologyNeuroscience

Identifiers

PMID42787691
PMCPMC13602872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.