Evidence map›Paper›PMID 42787686›Full record

ArticleFrontiers in oncology2025

Divergent evolution in bilateral prostate cancer: a case study.

Roni Haas, Rong Rong Huang, Adam B Weiner, Yash Patel, Lydia Y Liu, Takafumi N Yamaguchi, Raag Agrawal, Paul C Boutros, Robert E Reiter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Roni HaasDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, United States.
Rong Rong HuangDepartment of Pathology, University of California Los Angeles, Los Angeles, CA, United States.
Adam B WeinerDepartment of Urology, University of California Los Angeles, Los Angeles, CA, United States.
Yash PatelDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, United States.
Lydia Y LiuDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, United States.
Takafumi N YamaguchiDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, United States.
Raag AgrawalDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, United States.
Paul C BoutrosDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, United States.
Robert E ReiterDepartment of Urology, University of California Los Angeles, Los Angeles, CA, United States.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E · 2002 to 2023
$42.6M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Virginia-UCLA-Toronto Biomarker Characterization CenterU2CCA271894 · NCI · OLD DOMINION UNIVERSITY · PI Paul Christopher Boutros, OLIVER John SEMMES · 2022 to 2026
$3.2M
Germline Determinants of Prostate Cancer EvolutionR01CA270108 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL T. SPELLMAN · 2023 to 2026
$2.9M
NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA092131NCI NIH HHS R01 CA270108NCI NIH HHS U2C CA271894NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

Multifocal prostate cancer is a prevalent phenomenon, with most cases remaining uncharacterized from a genomic perspective. A patient presented with bilateral prostate cancer. On systematic biopsy, two indistinguishable clinicopathologic lesions were detected. Whole-genome sequencing displayed somatically unrelated tumors with distinct driver CNA regions, suggesting independent origins of the two tumors. We demonstrated that similar clinicopathologic multifocal tumors, which might be interpreted as clonal disease, can in fact represent independent cancers. Genetic prognostics can prevent mischaracterization of multifocal disease to enable optimal patient management.

Indexed as

clonal diseasedriver CNA regionsmultifocal prostate cancerprecision oncologyWGS characterization

Identifiers

PMID42787686
PMCPMC13601985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.