Evidence map›Paper›PMID 42787654›Full record

ArticleMolecular therapy. Nucleic acids2026

Integrated

Adithya Nair, Jixin Qu, Manoj Pohare, Thomas C Minshull, Caroline A Evans, Klaudia M Slowik, Kate A Loveday, Zoe V R Ashcroft, Mabrouka Maamra, Helen E Colley and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adithya NairSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Jixin QuSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Manoj PohareSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Thomas C MinshullSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Caroline A EvansSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Klaudia M SlowikSchool of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK.
Kate A LovedaySchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Zoe V R AshcroftSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Mabrouka MaamraSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Helen E ColleySchool of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK.
Craig MurdochSchool of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK.
Mark J DickmanSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Zoltán KisSchool of Chemical, Materials and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A platform process underpins the manufacturing of RNA-based vaccines and therapeutics. However, it remains constrained by high operational expenditures from costly reagents, inefficient raw-material utilization, and extensive purification. We report an integrated sequential-batch

Indexed as

5′ cap analogcritical quality attributesdouble-stranded RNAin vitro transcriptionmRNA manufacturingMT: Oligonucleotides: Therapies and Applicationsoligo-dT affinity chromatographyprocess integrationquality by designreagent recyclingsustainable bioprocessing

Identifiers

PMID42787654
PMCPMC13602715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.