ArticleVeterinarni medicina2026
Effects of vitamins A and E on eprinomectin transport in Caco-2 cells.
Article in Veterinarni medicina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Eprinomectin (EPR) is a macrocyclic lactone antiparasitic widely used in veterinary medicine. Although the off-label oral use of the pour-on formulation of EPR is known to be effective and practical, data regarding its interactions with foods or vitamin supplements that may affect intestinal absorption remain limited. This study investigated the effects of vitamin A (VA) and vitamin E (VE) on the transepithelial permeability of EPR using the Caco-2 cell monolayer model. An analytical method for EPR quantification was developed using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The integrity of tight junction dynamics in epithelial monolayers was monitored using transepithelial electrical resistance (TEER) throughout the 21-day differentiation protocol. Apparent permeability coefficients (
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