Evidence map›Paper›PMID 42787620›Full record

ArticleBioactive materials2027

An endoplasmic reticulum-enriched nanogel couples ferroptotic tumor damage with macrophage reprogramming for triple-negative breast cancer immunotherapy.

Heying Chen, Yilu Ni, Jiaruo Tang, Yongyuan Ma, Jie Zhang, Jiayu Zhang, Hongyan Sun, Jun Chen, Zhenglin Yang, Dongqing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heying ChenSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Yilu NiThe M.O.E. Key Laboratory of Laboratory Medical Diagnostics, The College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Jiaruo TangChinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100049, China.
Yongyuan MaMedical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
Jie ZhangDepartment of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, 999077, China.
Jiayu ZhangChinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100049, China.
Hongyan SunDepartment of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, 999077, China.
Jun ChenChinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100049, China.
Zhenglin YangSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Dongqing WangSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is characterized by severely immunosuppressive tumor microenvironment (TME), which leads to tumor ferroptosis resistance and dominant protumor M2 macrophages, restraining innate-to-adaptive antitumor immune cascade. Herein, an endoplasmic reticulum (ER)-enriched pH/redox-sensitive SPIONS@P-CpG-DOX nanogel was constructed to realize dual ER-targeted manipulation on TNBC cells and tumor-associated macrophages (TAMs) to elicit an ER-centered innate-to-adaptive immune amplification axis. In TNBC cells, nanogel-induced ER stress inhibits the GSH-GPX4 axis and accelerates lipid peroxidation, triggering ER-originated ferroptosis and immunogenic cell death (ICD) to release antigens and damage-associated molecular patterns (DAMPs) for immune priming. In macrophages, nanogel activates ER-dependent STING/NF-κB pathways without ferroptosis, facilitating M2-to-M1 polarization and inflammatory TME remodeling. The dual ER-initiated pathways synergistically facilitate dendritic cell (DC) maturation, enhance intratumoral CD4

Indexed as

ER-Enriched nanogelFerroptosisMacrophage reprogrammingSTING/NF-κB signalingTriple-negative breast cancer

Identifiers

PMID42787620
PMCPMC13602404

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.