ArticleAmerican journal of clinical and experimental urology2026
AZGP1 deficiency promotes chronic kidney fibrosis in aging mice.
Article in American journal of clinical and experimental urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesChronic kidney disease (CKD) affects 10-14% of the global population and is a leading cause of death. A hallmark of CKD is renal fibrosis, characterized by excessive extracellular matrix deposition. Although our understanding of fibrogenic mechanisms has advanced, effective antifibrotic therapies are lacking. Zinc-α2-glycoprotein 1 (AZGP1) regulates extracellular matrix remodeling in multiple organs, and we previously demonstrated that loss of AZGP1 induces fibrosis in the prostate.
methodsAZGP1 expression was analyzed in single-cell RNA sequencing data from the mouse kidney. Kidney tissues from wild-type and AZGP1
resultsAZGP1 is mainly expressed in the proximal tubule epithelial cell population. AZGP1-deficient (AZGP1
conclusionsThese findings identify AZGP1 expressed in proximal tubular cells as protective against kidney fibrosis associated with aging and is a candidate therapeutic target.
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