Evidence map›Paper›PMID 42787574›Full record

ArticleiScience2026

Levofloxacin enhances 5-fluorouracil efficacy in colorectal cancer by activating the DDR-TP53-mitochondrial apoptosis axis.

Chenmeng Huang, Chenchen Sun, Han Wang, Ying Wei, Yufei Zhang, Wenfeng Li, Aping Yue, Yajing Yang, Jiajia Wang, Jindan Guo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chenmeng HuangDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Chenchen SunHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Han WangShouzheng Pharma Biotechnology Co., Ltd, Wuhan, Hubei 430200, China.
Ying WeiDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Yufei ZhangDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Wenfeng LiDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Aping YueDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Yajing YangDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Jiajia WangDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Jindan GuoDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.
Zhengxi HuHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Jiangyang ChiSchool of Life Sciences, Hubei University, Wuhan, Hubei 430062, China.
Yongli FanDepartment of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Fluorouracil (5-FU)-based regimens are a cornerstone of colorectal cancer (CRC) chemotherapy. Levofloxacin (LVF), a widely used fluoroquinolone antibiotic, has been reported to exhibit anticancer properties. We investigated LVF's ability to enhance CRC chemosensitivity to 5-FU in cell lines, subcutaneous xenografts (Balb/c-nude mice), and spontaneous intestinal tumors (Apc

Indexed as

5-fluorouracilapoptosiscolorectal cancerDNA damagelevofloxacin

Identifiers

PMID42787574
PMCPMC13602227

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.