ArticleCureus2026
Therapeutic Augmentation of Intra-articular Hyaluronic Acid With Triamcinolone Acetonide and Lignocaine in the Management of Primary Knee Osteoarthritis: A Prospective Comparative Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
introductionPrimary osteoarthritis (OA) of the knee is a very common cause of pain and disability among the general population with advancing age. Intra-articular hyaluronic acid (HA) injections are widely used for symptomatic relief, while corticosteroids are known to provide rapid anti-inflammatory effects. This study compared intra-articular HA alone with HA combined with triamcinolone acetonide and lignocaine, with the primary objective of comparing the between-group change in Visual Analogue Scale (VAS) pain score from baseline to 12 months and providing a viable conservative treatment option for patients not immediately requiring surgical intervention.
methodsA prospective comparative study was conducted over 18 months. A
resultsThe mean VAS fell from 7.5±0.9 to 5.4±0.8 in Group A and from 7.6±0.8 to 3.4±0.7 in Group B by 12 months (between-group difference in change 2.1, p<0.001). At 12 months, fewer Group B patients required daily analgesics (29.1% vs 48.8%, p<0.001), and more reported excellent or good satisfaction (83.0% vs 60.5%, p<0.001), while adverse events were infrequent and comparable between groups aside from post-injection knee pain, which was less frequent in Group B (8.2% vs 17.3%, p=0.015).
conclusionThe addition of triamcinolone acetonide and lignocaine to intra-articular HA was associated with earlier pain relief, improved knee range of motion, reduced analgesic dependence, and higher patient satisfaction without increasing treatment-related complications. Combination therapy appears to be a safe and effective conservative treatment option for symptomatic primary knee OA not immediately requiring surgical intervention. However, because each arm was administered by a single, different surgeon, treatment and operator effects are fully confounded, and findings should be interpreted as reflecting the combined protocol rather than the drug regimen in isolation.
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