Evidence map›Paper›PMID 42787482›Full record

ArticleFrontiers in immunology2026

Limited effect of surfactant protein D ablation on doxorubicin-induced intestinal toxicity in mice.

Mathias Rathe, Sebastian von Huth, Faisal Fazli, Mark Burton, Mads Thomassen, Pingping Jiang, Jesper B Moeller, Uffe Holmskov, Steffen Husby, Grith L Sorensen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mathias Rathe *Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Sebastian von Huth *Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Faisal FazliDepartment of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Mark BurtonDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Pingping JiangSection of Comparative Pediatrics and Nutrition, Department of Clinical Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark.
Jesper B MoellerDepartment of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Uffe HolmskovDepartment of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Steffen HusbyHans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Grith L SorensenDepartment of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Surfactant protein (SP-D) is an anti-inflammatory host defense molecule, produced by epithelial cells and present on mucosal surfaces throughout the human and mouse body. In the present study, we investigated whether SP-D attenuates chemotherapy-induced gastrointestinal toxicity and inflammation in mice. Methods: SP-D knockout (KO, Results: Doxorubicin significantly reduced bodyweight, and KO mice lost significantly more weight relative to WT mice. Transcriptional analyses showed a significant SP-D-dependent increase of gasdermin genes ( Discussion: In conclusion, SP-D had a limited but significant impact on mouse gastrointestinal toxicity after chemotherapy-induced mucositis, which primarily involved weight loss of unknown cause and had no or limited effects on intestinal morphology and inflammation.

Indexed as

Antibiotics, AntineoplasticDoxorubicinMucositisPulmonary Surfactant-Associated Protein DAnimalsIntestinal MucosaMaleMiceMice, KnockoutAntibiotics, AntineoplasticDoxorubicinPulmonary Surfactant-Associated Protein Dchemotherapydoxorubicingastrointestinal toxicitymucositismurineSP-Dsurfactant protein D

Identifiers

PMID42787482
PMCPMC13602119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.