ArticleFrontiers in cardiovascular medicine2026
Multiparametric CMR evaluation of myocardial remodeling in dystrophinopathy.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cardiac involvement in dystrophinopathy progresses from diffuse myocardial remodeling to overt systolic failure. Multiparametric cardiac magnetic resonance (CMR) offers simultaneous insights into myocardial mechanics and tissue characterization, yet the optimal diagnostic parameters for tracking disease severity remain to be fully characterized. Objective: To objectively evaluate the descriptive and discriminative performance of integrating strain and quantitative T1 mapping parameters for identifying myocardial fibrosis burden and stratifying systolic dysfunction in patients with dystrophinopathy. Materials and methods: This retrospective study analyzed 55 patients with genetically confirmed dystrophinopathy and 30 healthy controls who underwent CMR between January 2020 and December 2024. Patients were sequentially stratified by late gadolinium enhancement (LGE) status (Group A: LGE-negative, Results: Compared with Group A, Group B exhibited significant differences in LVEF ( Conclusions: In dystrophinopathy, multiparametric CMR enables structural and functional assessment of myocardial remodeling. Segmental native T1, particularly in the basal and mid-inferolateral segments, provides complementary information on regional myocardial tissue abnormalities. In contrast, CS accounts for most of the discrimination of disease severity. These findings suggest that the distinctive contribution of CMR may lie in regional myocardial tissue characterization rather than conventional functional assessment.
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