Evidence map›Paper›PMID 42787468›Full record

ArticleBiochemistry and biophysics reports2026

Anti-proliferative and anti-inflammatory potential of 2-chloro-3-((4-hydroxyphenyl)amino)naphthalene-1,4-dione through targeting TNF-α/IL-8 and NF-κB signaling in HCT116 cancer cells: a comprehensive

Sakdiphong Punpai, Panupong Mahalapbutr, Panyakorn Taweechat, Ronnakorn Leechaisit, Kiattawee Choowongkomon, Ratchanok Pingaew, Wanlaya Tanechpongtamb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sakdiphong PunpaiInnovative Learning Center, Center of Excellence in Medical and Environmental Innovation Research (CEMEIR), Srinakharinwirot University, Bangkok, 10110, Thailand.
Panupong MahalapbutrDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Panyakorn TaweechatFaculty of Science Sports and Health Science, Thailand National Sports University Chonburi Campus, Chonburi, 20000, Thailand.
Ronnakorn LeechaisitDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand.
Kiattawee ChoowongkomonDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, 10903, Thailand.
Ratchanok PingaewDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand.
Wanlaya TanechpongtambDepartment of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, 10110, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is closely associated with chronic inflammation, and the NF-κB pathway acts as a central regulator of the inflammatory response that promotes tumor progression. In this study, we examined the anticancer and anti-inflammatory potential of anilino-1,4-naphthoquinone derivatives (compounds

Indexed as

1,4-NaphthoquinoneAnti-inflammationAnti-proliferationApoptosisColorectal cancer

Identifiers

PMID42787468
PMCPMC13602140

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.