ArticleFrontiers in microbiology2026
Microbiological quality control for intravaginal devices for the treatment of infectious diseases and bacterial vaginosis.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Preclinical and clinical infectious disease research introducing intravaginal devices containing active agents and probiotic bacteria need to rely on materials that meet appropriate microbiologic standards. However, research methods for quality control of intravaginal devices are poorly described. Here, we develop a practical workflow that specifies media types, culture techniques, and modifications to commonly used assays to suit vaginal applications. A set of quality control assays were developed to test electrospun fibers intended for use in an experimental (mouse) model. The fibers carried probiotics, antibiotics, or no cargo (i.e., "blank"). To validate anti-bacterial action for metronidazole-containing fibers against a relevant target bacterium associated with bacterial vaginosis (BV), a modified Kirby Bauer disc diffusion assay confirmed a zone of
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