ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Extracerebral microvascular burden links to dementia risk and brain structural changes: Evidence from a large-scale cohort study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe contribution of extracerebral microvascular disease (MVD) burden to dementia risk remains unclear.
methodsAmong 484,896 UK Biobank participants (median follow-up 8.5 years), baseline extracerebral MVD (retinopathy, nephropathy, peripheral neuropathy) and incident dementia were identified via hospital records. Aging-related brain changes were evaluated using magnetic resonance imaging (MRI) -derived volumes and white matter integrity.
resultsMVD was 2.6 times more prevalent among participants who developed dementia than dementia-free individuals (8.0% vs 3.1%) and ranked second among vascular comorbidities after coronary artery disease. Each additional MVD burden was associated with a higher dementia risk, comparable to coronary artery disease (hazard ratio = 1.69 vs. 1.72). Earlier onset conferred stronger risk, and coexisting vascular diseases further amplified associations ( DISCUSSION: Extracerebral MVD burden is associated with dementia risks and brain imaging changes, supporting integrated vascular risk stratification and management for dementia.
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