Evidence map›Paper›PMID 42787226›Full record

ArticleFrontiers in microbiology2026

An IS

Zaikun Xiong, Rucai Chen, Caibing Zhao, Qianyi Cheng, Xianyao Liang, Ying Hu, Xu Yang, Jinyuan Yan, Wei He, Li Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zaikun Xiong *Department of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Rucai Chen *Department of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Caibing Zhao *Department of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Qianyi ChengDepartment of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xianyao LiangDepartment of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Ying HuDepartment of Laboratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xu YangDepartment of Laboratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Jinyuan YanDepartment of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Wei HeDepartment of Laboratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Li ChenDepartment of Laboratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xinwei HuangDepartment of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Pengfei WangDepartment of Key Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Carbapenem-resistant Methods: In this study, we characterized a highly imipenem-resistant clinical ST11 CRKP isolate (W61) by combining whole-genome sequencing, conjugation assays, structural variation (SV) analysis, S1-PFGE, Southern blotting, and antibiotic susceptibility testing. Results: The isolate harbored a novel 224-kbp chimeric plasmid (pW61_1) and exhibited an imipenem minimum inhibitory concentration (MIC) of 512 μg/mL. Plasmid pW61_1 was composed of three modules fused through IS Discussion: Our findings demonstrate that the tri-modular plasmid is transferable and undergoes post-transfer rearrangement under laboratory conditions. We hypothesize that this tri-modular plasmid may play an important role in the dissemination of carbapenemase genes, and therefore continued surveillance of this plasmid and its rearranged derivatives is warranted.

Indexed as

blaKPC–2blaNDM–1carbapenem-resistant Klebsiella pneumoniaeconjugative transferIS26-mediated cointegrationplasmid evolutionstructural variation

Identifiers

PMID42787226
PMCPMC13601294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.