ArticleFrontiers in medicine2026
A rare case report of epithelioid hemangioendothelioma involving both lungs and right atrium with multi-system involvement.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epithelioid hemangioendothelioma (EHE) is a rare low-grade malignant vascular neoplasm characterized by local aggressiveness and metastatic potential. Clinically, EHE may involve multiple anatomical sites-including the lungs, liver, bones, and soft tissues-either synchronously or metachronously. Its non-specific clinical manifestations often complicate early diagnosis. Given the extreme rarity of documented cases in the literature, we report a rare case of right atrial EHE with concurrent bilateral pulmonary and extensive systemic metastases. Furthermore, we present a comprehensive literature review to explore the diagnostic and therapeutic challenges associated with this disease. We particularly emphasize the necessity of a thorough diagnostic evaluation encompassing both pathological and imaging modalities to ensure accurate characterization and diagnosis of the tumor in this case.
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