Impact of early post-pyloric feeding during therapeutic hypothermia on outcomes in patients with traumatic brain injury: a retrospective cohort study.

Qiuhong He, Yang Hu, Xiaoli Du, Fengmei Li, Dan Wen, Dan Zhang

Abstract read

In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiuhong He *Intensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Yang Hu *Intensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Xiaoli DuIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Fengmei LiIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Dan WenIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Dan ZhangIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although therapeutic hypothermia (TH) is a standard critical care intervention for traumatic brain injury (TBI), it can significantly suppress gastrointestinal motility, leading to feeding intolerance (FI) rates as high as 40%-70%. Post-pyloric feeding (PPF), which bypasses the stomach, offers a potential solution. Nevertheless, the efficacy of PPF in improving outcomes for TBI patients receiving TH has not been established. Objective: This study aimed to compare the effects of early post-pyloric feeding versus conventional nasogastric tube feeding on neurological outcomes and clinical endpoints in TBI patients undergoing therapeutic hypothermia. Methods: In this single-center, retrospective cohort study conducted between January 2024 and June 2025, 122 eligible TBI patients were enrolled. Based on the enteral nutrition route established within 48 h of intensive care unit (ICU) admission, patients were divided into a PPF group ( Results: No statistically significant differences were observed between the PPF and NGT groups in the 30-day favorable neurological outcome rate (29.85% vs. 30.91%, Conclusion: Although early PPF did not significantly improve short-term mortality or neurological outcomes in TBI patients undergoing TH, it effectively reduced the incidence of FI and shortened the duration of mechanical ventilation and ICU stay.

Indexed as

enteral nutritionfeeding intolerancepost-pyloric feedingtherapeutic hypothermiatraumatic brain injury

Identifiers

PMID42787186

DOI10.3389/fmed.2026.1924713

PMCPMC13601261

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.