ArticleFrontiers in veterinary science2026
Combined tibial plateau leveling osteotomy and autologous conditioned serum for functional recovery and delayed osteoarthritis progression in dogs with cranial cruciate ligament rupture.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cranial cruciate ligament rupture (CCLR) is the leading cause of stifle joint instability, chronic pain, and osteoarthritis (OA) in dogs. Although tibial plateau leveling osteotomy (TPLO) is the standard surgical treatment, postoperative inflammation and secondary OA progression remain major challenges. Autologous conditioned serum (ACS) is a biological therapy with anti-inflammatory and chondroprotective properties. Methods: In this prospective, randomized controlled trial, 60 stifles (48 client-owned dogs) with complete CCLR were allocated equally to three groups ( Results: All groups showed significant functional improvement ( Conclusion: TPLO combined with ACS provides great improvement for canine CCLR by restoring biomechanical stability and modulating the intra-articular inflammatory microenvironment. This integrated approach enhances functional recovery and retards OA progression.
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