ArticleFrontiers in veterinary science2026
Exploring the impact of sanguinarine on lamb immunity based on gut microbiota and metabolomics.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Sanguinarine (SNG), a benzophenanthridine alkaloid derived from Methods: Lambs received dietary SNG extract at 200 or 800 mg/kg body weight (equivalent to 4 and 16 mg/kg BW pure SNG, respectively). Growth performance, serum immune-antioxidant indices, gut microbiota, and metabolomics profiles were determined to evaluate the treatment effects. Results: SNG supplementation significantly increased average daily gain, up-regulated serum IgG, IL-6 and IFN-γ, and down-regulated IL-4 and IL-10. Antioxidant enzyme activities decreased, whereas malondialdehyde concentration was not altered. Microbiota analysis showed reduced Discussion: Our findings indicate that SNG improves growth performance and immune function in lambs by reshaping gut microbiota and reprogramming host lipid metabolism. This work provides mechanistic support for the application of SNG as a functional feed additive for ruminants.
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