ArticleFrontiers in cellular neuroscience2026
Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder.
Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Opioid Use Disorder (OUD) is a chronic condition characterized by compulsive opioid intake that drives widespread health, social, and economic burdens. Methods: To elucidate molecular contributors to addiction susceptibility, we conducted a comprehensive RNA-sequencing analysis of postmortem nucleus accumbens (NAc) tissue from individuals with OUD and matched controls. Results: Cohort-concordance filtering identified 17 candidate missense variants and one candidate stop-gain variant across 16 genes detected in OUD samples; these RDEVs require DNA-based validation. Missense variants could disrupt key protein domains, and five of these identified variants ( Discussion: Together, these findings provide an integrated view of candidate genetic and transcriptomic alterations in OUD and identify lncRNA-centered regulatory networks and candidate variant-bearing genes as hypothesis-generating leads for future functional and DNA-based validation studies.
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