ArticleFrontiers in physiology2026
Erythroid anion exchanger-1 (SLC4A1) modulates carbonic anhydrase inhibitor acetazolamide on respiration.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Introduction: Clinically widely used acetazolamide is a potent carbonic anhydrase (CA) inhibitor. CA accelerates CO Methods: To explore whether erythroid AE1 could modulate the respiratory effects of acetazolamide, we utilized the GPMur mouse model characteristic of higher erythroid AE1 expression for respiratory measurements using whole-body plethysmography (WBP). The effects of acetazolamide and hypercapnia on murine respiration were compared. Results: We found that acetazolamide influenced respiration in the same direction as hypercapnia. Increased erythroid AE1 expression (GPMur) counteracted the impacts of hypercapnia/acetazolamide. Importantly, GPMur/higher AE1 increased respiratory sensitivity and limited responses to acetazolamide. Conclusion: Both acetazolamide and hypercapnia drove acidosis. GPMur/increased AE1 reduced the impacts of acidosis with faster respiratory responses. This supports that AE1 and CAII function in concert to facilitate intraerythrocytic CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.