ArticleMicrobiologyOpen2026
Carotenoid-Rich Pigment Extract From Micrococcus terreus SK34 Induces Apoptosis in SH-SY5Y Neuroblastoma Cells: Integrated Metabolomic, Molecular Docking, and Experimental Validation.
Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bacteria-derived carotenoids have attracted increasing attention as natural bioactive compounds with potential pharmaceutical applications, particularly in cancer therapy. However, the chemical composition and anticancer mechanisms of carotenoids from Micrococcus terreus remain largely unexplored. This study aimed to characterize the carotenoid extract from the locally isolated M. terreus SK34 strain (GenBank: PX765938) and to investigate its anticancer activity and underlying mechanisms using integrated in vitro and in silico approaches. Under nonoptimized culture conditions, strain SK34 produced 128 mg/L of carotenoid-rich pigment extract. LC-Q-TOF-MS analysis identified eight carotenoids, including phytoene, β-carotene, astaxanthin, zeaxanthin, β-cryptoxanthin, α-carotene, lycopene, and sarcinaxanthin. The extract exerted selective cytotoxicity against different cancer cell lines (IC
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