ArticleHuman brain mapping2026
DTI-ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi-Modal MRI.
Article in Human brain mapping, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The glymphatic system facilitates clearance of metabolic waste and pathological proteins from the brain, and its dysfunction has been implicated in neurodegenerative disease. The diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) has been proposed as a non-invasive MRI marker of glymphatic flow, although its biological specificity remains uncertain. This study aimed to identify the determinants of DTI-ALPS and evaluate whether it primarily reflects white-matter (WM) microstructure rather than glymphatic flow in the context of neurodegeneration. We examined 100 individuals referred to the Memory Clinic of the Policlinico Hospital in Milan for suspected dementia. All participants underwent a 3T-MRI protocol including 3D-T1-weighted and 3D-FLAIR imaging, double-shell diffusion-weighted imaging (b = 1000/2000 s/mm
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