Evidence map›Paper›PMID 42786706›Full record

ArticleJournal of applied clinical medical physics2026

Evaluation of a Faraday cup-style detector as a beam diagnostic system for ultra-high dose rate (FLASH) electron beams.

Alan Lopez, Alexander Baikalov, Kevin Liu, Nolan Esplen, Stefan Bartzsch, Emil Schüler

Abstract readEvaluation Study
In one paragraph

Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alan LopezDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Alexander BaikalovDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Kevin LiuDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-0942-6513
Nolan EsplenDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Stefan BartzschDepartment of Radiation Oncology, School of Medicine and Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Emil SchülerDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Research Supplements to Promote Diversity in Health-Related Research: Preclinical optimization of ultra-high dose rate (FLASH) radiotherapy parameters for translational relevanceR01CA266673 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SCHUELER, EMIL · 2022 to 2025
$3.5M
MD Anderson's Division of Radiation Oncology; by Cancer Center Support (Core) P30 CA016672NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA266673NIH HHS R01CA266673
6 · The paper itself

Abstract

backgroundBeam diagnostic systems are essential for the development and quality assurance of ultra-high dose rate (UHDR) radiation sources to enable reliable delivery of FLASH radiotherapy (RT). Critically, suitable beam diagnostic systems for electron FLASH sources are lacking. PURPOSE: In this study, we evaluated a Faraday cup-style beam collector (BC), the BC-145-Al, on an UHDR electron linac for FLASH-RT applications.

methodsThe BC performance was benchmarked against a reference alternating-current current transformer (ACCT) across a wide range of beam currents and pulse structures to test the BC's charge linearity and signal resolution capabilities. Two termination impedances were tested: 200 kΩ and 13 Ω.

resultsThe highly time-resolved signal of the BC was charge-proportional when terminated at 200 kΩ and current-proportional when terminated at 13 Ω, agreeing well with the time-resolved ACCT signal. The cumulative signals from the BC and ACCT showed excellent agreement, maintaining linearity with a deviation of less than ± 0.5% over 50 consecutive pulses (4-µs pulse width, 120-Hz pulse repetition frequency [PRF]). The BC/ACCT signal ratio remained stable within ± 0.5% as the PRF increased from 5 to 120 Hz at constant pulse width. Pulse width measurements from both detectors were also consistent within ± 0.5% across all nominal pulse width values (0.5-4 µs). When the charge per pulse was modulated by either increasing the pulse width or decreasing the source-to-surface distance (from 32.3 to 19.3 cm), the BC signal remained approximately linear with respect to the ACCT signal; however, the BC/ACCT ratio deviated by up to ± 6% across this range.

conclusionsThe BC produced highly time-resolved absolute charge measurements of a pulsed UHDR electron beam across a large range of beam parameters. These results support its potential as a beam diagnostic system for both preclinical studies and clinical applications of electron FLASH radiotherapy.

Indexed as

ElectronsParticle AcceleratorsPhantoms, ImagingQuality Assurance, Health CareRadiometryRadiotherapy Planning, Computer-AssistedEquipment DesignHumansRadiotherapy Dosagebeam diagnosticsFaraday cupFLASH radiotherapyultra‐high dose rate

Identifiers

PMID42786706
PMCPMC13612965

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.