Evidence map›Paper›PMID 42786570›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Tunable Sulfenylnitrenes Enable Scaffold Hopping of Furans Into N-Heterocycles.

Prakash Kafle, Prabhat Kharel, Rishav Mukherjee, Shuhei Yasuda, Deacon Herndon, Rylan C Fox, Daillin L Perez, Novruz G Akhmedov, Indrajeet Sharma

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Prakash Kafle *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID https://orcid.org/0009-0006-2069-7011
Prabhat Kharel *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID https://orcid.org/0009-0001-8242-5939
Rishav Mukherjee *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Shuhei Yasuda *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID https://orcid.org/0009-0009-6835-6429
Deacon HerndonDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Rylan C FoxDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Daillin L PerezDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID https://orcid.org/0009-0009-9986-0097
Novruz G AkhmedovDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Indrajeet SharmaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID https://orcid.org/0000-0002-0707-0621

Funding

LEVERAGING SULFUR SYNERGY WITH CARBENES/NITRENES FOR SITE-SELECTIVE TRANSFORMATIONSR01GM162731 · NIGMS · UNIVERSITY OF OKLAHOMA · PI Srinivas Chamakuri, Indrajeet Sharma · 2026 to 2026
$360k
American Chemical Society Petroleum Research Fund 69051-ND1NIGMS NIH HHS R01 GM162731NIGMS NIH HHS R01GM162731
6 · The paper itself

Abstract

Furans are readily available heteroaromatic scaffolds valued for their structural rigidity, tunable electronic properties, and functional versatility. Transforming furans into nitrogen-containing heterocycles is an efficient strategy for expanding molecular diversity and enhancing chemical and biological properties. N-heterocycles such as pyrimidines, pyrroles, and pyridazines often exhibit improved stability, enhanced hydrogen-bonding capacity, and favorable pharmacokinetic profiles. Herein, we report a scaffold-hopping strategy that converts furans into N-heterocycles using tunable sulfenylnitrenes. Mechanistic investigations, including isotopic labeling experiments supported by DFT calculations, reveal a unique reaction pathway.

Identifiers

PMID42786570
PMCPMC13659767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.