ArticleVeterinary research2026
Recombinant GI-19 infectious bronchitis virus induction of humoral immunosuppression with reduced HI antibody response following Newcastle disease virus vaccination and bursal cell apoptosis.
Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pathological changes and viral presence in the bursa of Fabricius (BF) have been reported, but the immunosuppression of infectious bronchitis virus (IBV) remains poorly characterized. Here, we systematically evaluated the pathogenicity of two GI-19 lineage IBV isolates, CK/CH/FJ-B3/2023 (bursal origin) and CK/CH/FJ-T5/2023 (tracheal origin), in 7-day-old specific pathogen-free (SPF) chicks, including further assessments of serum cytokines and the bursal apoptosis. We further assessed the impacts of these two IBV isolates on the Newcastle disease virus (NDV) inactivated vaccine-induced hemagglutination inhibition (HI) antibody response. This study reveals that both GI-19 lineage IBV isolates, which originated from the recombination of the 4/91 vaccine strain, exhibit bursa-tropism, inducing bursal pathological atrophy, prolonged viral detection [up to 35 days post-infection (dpi)] and delayed seroconversion until 14 dpi. Notably, IBV infection induces humoral immunosuppression in SPF chickens, evidenced by a ≥ 1log
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