ArticleBMC chemistry2026
Drug-delivery oriented solubility enhancement of curcumin in choline chloride-based acidic deep eutectic solvents: thermodynamic analysis and MCF-7 cytotoxicity assessment.
Article in BMC chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Curcumin is a bioactive compound with well-established chemopreventive and anticancer properties, but its pharmaceutical application is limited by extremely low aqueous solubility and poor formulation-dependent bioavailability. In this study, three choline chloride-based acidic deep eutectic solvents (ADESs), namely choline chloride/propionic acid (ChCl/Pro), choline chloride/acetic acid (ChCl/Ace), and choline chloride/lactic acid (ChCl/Lac), were systematically evaluated as solubilizing media for curcumin. The mole fraction solubility of curcumin was determined in aqueous ADES mixtures over 298.15-313.15 K at different ADES mass fractions. In all systems, solubility increased with both temperature and ADES content, and the overall solubilization efficiency followed the order ChCl/Pro > ChCl/Ace > ChCl/Lac. The highest solubility was obtained in neat ChCl/Pro at 313.15 K, where the mole fraction solubility reached 2.237 × 10
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