Evidence map›Paper›PMID 42786300›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Loss of C3 and CD14 reduces region-specific neuroinflammation in a murine polytrauma model.

Florian Olde Heuvel, Marica Pagliarini, Fan Sun, Ludmila Lupu, Zongren Zhao, Likun Cui, Jin Zhang, Rebecca Halbgebauer, Marco Mannes, Tobias Maria Boeckers and 5 more

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Florian Olde Heuvel *Department of Neurology, UIm University, Ulm, Germany.
Marica Pagliarini *Department of Neurology, UIm University, Ulm, Germany.
Fan Sun *Department of Neurology, UIm University, Ulm, Germany.
Ludmila LupuInstitute of Clinical and Experimental Trauma Immunology, Ulm University Medical Center, Ulm, Germany.
Zongren ZhaoDepartment of Neurology, UIm University, Ulm, Germany.
Likun CuiDepartment of Neurology, UIm University, Ulm, Germany.
Jin ZhangDepartment of Neurology, UIm University, Ulm, Germany.
Rebecca HalbgebauerInstitute of Clinical and Experimental Trauma Immunology, Ulm University Medical Center, Ulm, Germany.
Marco MannesInstitute of Clinical and Experimental Trauma Immunology, Ulm University Medical Center, Ulm, Germany.
Tobias Maria BoeckersInstitute of Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Bernd KnöllInstitute of Neurobiochemistry, Ulm University, Ulm, Germany.
Egil LienDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Tom Eirik MollnesDepartment of Immunology, Oslo University Hospital, Oslo, Norway.
Markus Huber-LangInstitute of Clinical and Experimental Trauma Immunology, Ulm University Medical Center, Ulm, Germany. markus.huber-lang@uniklinik-ulm.de.
Francesco RoselliDepartment of Neurology, UIm University, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTBI-polytrauma (P-TBI) is associated with acute neurological deterioration, delirium, and poor prognosis. Systemic inflammatory mediators are thought to amplify the cerebral neuroimmune response, particularly microglial activation, with detrimental consequences.

methodsWe investigated the roles of complement factor C3 and the TLR co-receptor CD14 in a murine polytrauma model combining mild TBI with femur fracture, blunt thorax trauma, and resuscitated haemorrhagic shock, using mice lacking C3, CD14, or both.

resultsP-TBI induced a rapid, brain-wide increase in inflammatory cytokines with region-specific patterns. TNF and CCL2 mRNA were upregulated in microglia in the cortex, hippocampus, and striatum, and this response was abolished in C3

conclusionThus, C3 and CD14 are dispensable for the acute response at the injury site but differentially regulate microglial and neuronal activation in remote brain regions, representing potential targets to reduce P-TBI-associated encephalopathy.

Indexed as

Complement C3Lipopolysaccharide ReceptorsMultiple TraumaNeuroinflammatory DiseasesAnimalsBrainCytokinesDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaC3 protein, mouseCd14 protein, mouseComplement C3CytokinesLipopolysaccharide ReceptorsComplementCortexDeliriumMicrogliaPolytraumaStriatumTNF

Identifiers

PMID42786300
PMCPMC13612673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.