Evidence map›Paper›PMID 42786295›Full record

ArticleCardiovascular and interventional radiology2026

Quantitative Comparison of Yettirium-90 (Y90) PET/CT and Y90 SPECT/CT Voxel-Based Dosimetry post Resin Y90 Microsphere Radioembolization.

Haneyeh Shahbazian, Johannes L Du Pisane, David Brandon, James R Galt, S Cheenu Kappadath, David M Schuster, Minzhi Xing, Ali Afrasiabi, Sandra Gad, Nima Kokabi

Registry-linked trialAbstract read
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In one paragraph

Article in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04172714 (Theragnostic Low Dose Y90 Microspheres for Personalized Y90 Radioembolization Dosimetry Planning), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04172714 nacompletednot on this map

Theragnostic Low Dose Y90 Microspheres for Personalized Y90 Radioembolization Dosimetry Planning

TypeinterventionalSponsorEmory UniversityRan2019 to 2021Enrolled30ConditionsHCC, Cancer of Liver, CancerArmsSIR-Spheres microspheres
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haneyeh ShahbazianDivision of Interventional Radiology, Department of Radiology, University of North Carolina, 101 Manning Drive, Chapel Hill, NC, 27514, USA.
Johannes L Du PisaneDivision of Interventional Radiology, Department of Radiology, University of North Carolina, 101 Manning Drive, Chapel Hill, NC, 27514, USA.
David BrandonDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
James R GaltDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
S Cheenu KappadathDivision of Nuclear Medicine, Department of Radiology, MD Anderson Cancer Center, University of Texas at Houston, Houston, TX, USA.
David M SchusterDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Minzhi XingGillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Ali AfrasiabiDivision of Interventional Radiology, Department of Radiology, University of North Carolina, 101 Manning Drive, Chapel Hill, NC, 27514, USA.
Sandra GadDivision of Interventional Radiology, Department of Radiology, University of North Carolina, 101 Manning Drive, Chapel Hill, NC, 27514, USA.
Nima KokabiDivision of Interventional Radiology, Department of Radiology, University of North Carolina, 101 Manning Drive, Chapel Hill, NC, 27514, USA. Nima_Kokabi@med.unc.edu.ORCID http://orcid.org/0000-0002-4569-2720

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo quantitatively compare Y90 PET/CT and Y90 SPECT/CT voxel-based dosimetry after RESIN Y90 TARE in hepatocellular carcinoma (HCC). This was a secondary aim of a previously published prospective single-center trial evaluating low-dose scout RESIN Y90 for treatment planning (NCT04172714). MATERIALS AND

methodsThirty patients with 33 treatment-naïve HCC lesions underwent Y90 PET/CT and SPECT/CT after scout and therapeutic RESIN Y90. Voxel-based dosimetry (local deposition method) yielded mean, minimum, and the mean dose to the highest-dosed 30% (V30) and 70% (V70) of the volume, for tumor dose (TD) and non-tumoral liver dose (NTLD). Identical PET/CT-derived contours were applied to the SPECT/CT, and agreement was assessed by Bland-Altman analysis and intraclass correlation (ICC).

resultsTD-mean (494 vs. 366 Gy), TD-V30 (594 vs. 408 Gy), and TD-V70 (405 vs. 326 Gy) were higher on PET/CT than SPECT/CT, while NTLD-mean (103 vs. 182 Gy) and NTLD-V70 (77 vs. 141 Gy) were lower on PET/CT (all p < 0.001). Correlations were very strong for TD-mean, TD-min, TD-V30, TD-V70, NTLD-mean, and NTLD-V30 (r > 0.9). Relative to PET/CT, SPECT/CT underestimated TD-mean by 127 Gy (95% limits of agreement -435 to 181 Gy) and overestimated NTLD-mean by 79 Gy; ICC was low for several non-tumoral endpoints (NTLD-mean 0.57, 95% CI -0.09 to 0.86) despite strong correlation.

conclusionsAfter RESIN Y90 TARE for HCC, PET/CT calculated higher TD and lower NTLD than SPECT/CT, correlating strongly but with a potentially clinically relevant systematic bias and wide limits of agreement. The modalities should not be considered interchangeable without modality-specific thresholds or further validation.

Indexed as

HCCNon-tumoral liver doseSelective internal radiation therapyTARETransarterial radioembolizationTumor doseYttrium-90-PET/CTYttrium-90 radioembolizationYttrium-90-SPECT/CT

Identifiers

PMID42786295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.